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How to mix and prepare Similac® powder baby formula · 1. Measure 23 fl oz of water using a liquid measuring cup. · 2. Add 1 cup (100 g†) of powder, unpacked and Preparation of Similac NeoSure®. (Infant Formula) 22 Calories/Ounce. • Pour desired amount of water in container. • Add powder. • Shake or stir well. This formula helps with “catch up” growth, including weight, length and head circumference. NeoSure® usually contains 22 calories per ounce, but some babies may Similac NeoSure is complete nutrition* for babies born prematurely. Our post-discharge baby formula has increased protein, vitamins, and minerals comparedinfant formula is normally mixed to provide 22 calories per ounce. Your infant needs higher calorie formula. Follow these instructions closely when mixing