Zoledronic acid infusion guidelines

The zoledronic acid infusion time must not be less than 15 minutes given over a constant infusion rate. The i.v. infusion should be followed by a 10 mL normal fileslib. The recommended dose for the treatment of postmenopausal osteoporosis is 5 mg of zoledronic acid in 100 mL ready to infuse solution. It is administered Protocol for the Administration of Intravenous Zoledronic Acid for the Management of Osteoporosis and Paget's Disease. Version 2. Rheumatology.
Zoledronic acid should be infused over a period of at least 30 minutes . In patients taking other nephrotoxic drugs or diuretics, periodic postinfusion measurement of serum creatinine should be considered. Zoledronic acid is not recommended for use in patients with creatinine clearance ≤35 mL/min [49].
The infusion protocol for zoledronic acid is briefly outlined in Table 1 . The maximum recommended zoledronic acid dose for the treatment of bone metastases