Generations of cephalosporins pdf

Pallares R. Cephalosporins as risk factor for nosocomial Enterococcus faecalis bacteremia. Arch. Intern. 5TH GENERATION. CEPHALOSPORINS. Dr.T.V.Rao MD. DR.T.V.RAO MD 1 WHAT ARE CEPHALOSPORINS • The cephalosporins structurally related to the penicillin's consist of a -beta lactam ring attached to a dihydrothiazoline ring. Substitutions of chemical groups result in varying pharmacologic properties and antimicrobial activities . DR.T.V.RAO MD 2 HISTORY OF CEPHALOSPORINS • Cephalosporin to 3rd generation cephalosporins in, e.g. K. pneumoniae and E. coli in human infections is increasing in Europe. Many of these problems in human medicine can be correlated to use of cephalosporins and other antimicrobials in humans, but it is possible that spread from animal reservoirs via food or via the PDF | On Apr 1, 2015, Arshed Hussain and others published RESISTANCE PATTERN OF 3RD GENERATION CEPHALOSPORINS | Find, read and cite all the research you need on ResearchGate Third-generation - act primarily against gramnegative organisms and are the drug of choice for anaerobic organisms. Fourth-generation - active against a wide range of gram-positive and negative bacteria. f ( 1st generation) Cefalexin f ( 1st generation) Cefadroxil f ( 1st generation) Cefradine f (2nd generation) Cefaclor generation and gram-negative activity equivalent to third-generation cephalosporins (Harrison et al, 2008). Third generation cephalosporins are less active against gram positive cocci. . * Corresponding Author doctor.bushra@hotmail.com Phone number: 92-21-36620857-9 Fax number: 92-21-36620614